I know a few people I'd send this to just to watch their reaction. And snap photos.
The simplicity of the victim flies and the irregularity of the neck jewelry belie a certain complexity in the subject matter, somewhere between the innocent upward glance of the girly-girl toward her apparent guardian, or familiar spirit (if she is a sorceress). Wreathed in spider's silk and peppered with her man's underlings, it shows childlike innocence in a way rarely spoken: that their curiosity and wonder supersede any preservation instincts. Most people smash spiders if they're not too busy freaking out in their presence. Others will let them be, knowing they pick off other lesser beings fluttering through the household. Still others, like this girl, will let them keep her warm at night.
Hate to sound ironic, but that's damned sexy. I like it (rather, PREFER IT) when girls can keep their composure when faced with the little things in life. Reminiscent of those fantasy images of werespiders, with the torso of a hottie replacing the head of a black widow or other such nefarious specimen, only that here, the cute woman is the friend and master of countless spiders, some fist-sized. The way they should be.
In another fit of symbolism, she could be somehow above the snares of her many boyfriends, seeing how they might crawl around her, but she does not seem all too concerned, and her innocent guise and expression only compound her inherent allure. Besides, if they really are together, there is that chance that she must devour her mate if he wishes to breed, so that implies a level of control.
In other words, physical beauty aside, there is a lot that makes the subject of the piece a desirable ideal, even if most people will brush it off as purely a darkly fantastic horror piece (it's far too silly for that label).
I've noticed across several of your works that you're definitely a fantasy illustrator like out of "Heavy Metal" Magazine, with a serious glamour bent. This deserved its Front Page status. Heh, this deserves to be plastered on desktops, either as a reminder of what to shoot for or just because it's too damn horror-cute to pass up.